On mathematical modeling of vitamin C role in the tripartite synapse, calcium waves, and neurodegenerative diseases
Abstract
The main goal is to initiate the young mathematicians in this mysterious world of vitamin C role in our brain. Information that may be useful for tripartite synapse mathematical modeling is collected. The volume of this knowledge is enormous and constantly growing. As a starting point, one needs to understand how ascorbic acid (vitamin C) changes during synaptic activity and how it is astrocyte-mediated recycling from oxidized ascorbic acid back. The paper contains elementary insight into neurons, action potential, and the energy supply to the brain. Three mathematical models of calcium waves are briefly mentioned, and the role of vitamin C in calcium channel regulation is explained. The conclusion contains a discussion about the birth of a new science – neuro-gastroenterology.
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